Treatment utilizing the Calmare® medical device is restricted to allopathic physicians and other qualified licensed healthcare professionals under their direct supervision who are certified in its use and application and are familiar with the principles, clinical applications, side effects and hazards associated with transdermal pain modulation.
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Scrambler therapy improves pain in neuromyelitis optica
Maureen A. Mealy, View ORCID ProfileSharon L. Kozachik, Lawrence J. Cook, Lauren Totonis, Ruth Andrea Salazar, Jerilyn K. Allen, Marie T. Nolan, Thomas J. Smith, Michael LevyNeurology. 2020 Apr 8. [Epub ahead of print]
doi: 10.1212/WNL.0000000000009370 -
Decreased Low Back Pain Intensity and Differential Gene Expression Following Calmare®: Results From a Double-Blinded Randomized Sham-Controlled Study
Angela R. Starkweather, Patrick Coyne, Debra E. Lyon, R. K. Elswick Jr., Kyungeh An, Jamie SturgillRes. Nurs. Health. 38: 29-38
PMID: 25572279
doi: 10.1002/nur.21632 -
Treatment of Postherpetic Pain With Scrambler Therapy, a Patient-Specific Neurocutaneous Electrical Stimulation Device
Thomas J. Smith, MD, Giuseppe Marineo, ScDAm J Hosp Palliat Care. 2013 Jul 8. [Epub ahead of print]
PMID: 23838448
doi: 10.1177/1049909113494002 -
Clinical Experiences on the Effect of Scrambler Therapy for Patients with Postherpetic Neuralgia
Young Kwon Ko, MD, Ho Young Lee, MD and Wang Yong Lee, MDKorean J Pain. 2013 Jan;26(1):98-101.
PMID: 23342218
PMCID: PMC3546221
doi: 10.3344/kjp.2013.26.1.98 -
Scrambler Therapy May Relieve Chronic Neuropathic Pain More Effectively Than Guideline-Based Drug Management: Results of a Pilot, Randomized, Controlled Trial
Giuseppe Marineo, PhD, Vittorio Iorno, MD, Cristiano Gandini, MD, Vincenzo Moschini, MD and Thomas J. Smith, MDJ Pain Symptom Manage. 2012 Jan;43(1):87-95.
PII S0885-3924(11)00264-8
doi: 10.1016/j.jpainsymman.2011.03.015 -
Pilot Trial of a Patient-Specific Cutaneous Electrostimulation Device (MC5-A Calmare®) for Chemotherapy-Induced Peripheral Neuropathy
Thomas J. Smith, MD, Patrick J. Coyne, RN, MSN, Gwendolyn L. Parker, RN, MSN, Patricia Dodson, RN, MSN, and Viswanathan Ramakrishnan, PhDJ Pain Symptom Manage. 2010 Dec;40(6):883-91.
PII S0885-3924(10)00521-X
PMID: 20813492
doi: 10.1016/j.jpainsymman.2010.03.022 - Scrambler therapy
- Untreatable Pain Resulting from Abdominal Cancer: New Hope from Biophysics?
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Artificial Neurons in oncological pain: the potential of Scrambler Therapy to modify a biological information
G. Marineo, S. Spaziani, A.F. Sabato, F. MarottaInternational Congress Series 1255 (2003) 381-388
doi: 10.1016/S0531-5131(03)00661-7
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Scrambler Therapy in the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy
NCT ID: NCT02111174
Sponsor: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins
Principal Investigator: Thomas J. Smith
Protocol IDs: J1384, NA_00086429 -
Trial of Scrambler Therapy or Sham Treatment for Low Back Pain
NCT ID: NCT01896687
Sponsor: Virginia Commonwealth University, School of Nursing
Principal Investigator: Angela Starkweather
Protocol IDs: SCRA-LBP -
Scrambler Therapy in Treating Chronic Pain in Patients With Rash From Varicella Zoster Virus Infection
NCT ID: NCT01347736
Sponsor: Mayo Clinic
Principal Investigator: Charles L. Loprinzi
Protocol IDs: MC10CE, NCI-2011-00338 -
Scrambler Therapy in Treating Pain and Peripheral Neuropathy in Patients Previously Treated With Chemotherapy
NCT ID: NCT01347723
Sponsor: Mayo Clinic
Principal Investigator: Charles L. Loprinzi
Protocol IDs: MC10CC, NCI-2011-00339 -
MC5-A Scrambler Therapy in Reducing Peripheral Neuropathy Caused by Chemotherapy
NCT ID: NCT01290224
Sponsor: Mayo Clinic
Principal Investigator: Charles L. Loprinzi
Protocol IDs: MC10C8, NCI-2011-00109, 10-007874 -
MC-5A for Chemotherapy Induced Peripheral Neuropathy
NCT ID: NCT01261780
Sponsor: University of Wisconsin, Madison
Principal Investigator: Toby Campbell
Protocol IDs: OS10328 -
Electrical Stimulation Pain Therapy in Treating Chronic Pain and Numbness Caused By Chemotherapy in Patients With Cancer
NCT ID: NCT01196442
Sponsor: Virginia Commonwealth University, Massey Cancer Center
Principal Investigator: Craig Swainey
Protocol IDs: MCC-13098, NCI-2010-01945 -
Electrical Stimulation Therapy Using the MC5-A Scrambler in Reducing Peripheral Neuropathy Caused by Chemotherapy
NCT ID: NCT00952848
Sponsor: Virginia Commonwealth University, Massey Cancer Center
Principal Investigator: Thomas J. Smith
Protocol IDs: CDR0000644516, MCV-MCC-12110
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Treatment of Chronic Neuropathic Pain Caused by Chemotherapy
Competitive Technologies, Inc.
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Corneal Neuropathic Pain
Perry Rosenthal, MDBoston Foundation for Sight; Harvard Medical School
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MC-5A for Painful Chemotherapy-induced Peripheral Neuropathy
Toby Campbell, MD, MSCIPaul Carbone Cancer Center, University of Wisconsin
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Application of Information Theory in Pain Therapy
Stephen J. D'Amato, MDCalmar Pain Relief, LLC